Мы обучаем миссионеров, как организовать служение благовестия, чтобы люди понимали то, что они читают в Библии. Мы понимаем, что миссионеры, как солдаты, нуждаются в двух вещах: в оружии (Слове Божьем) и в обучении им пользоваться, и учим их этом. Мы уверенны, что именно через совместное изучение Священного Писания, люди будут приходить ко Христу и идти дальше, не теряясь «по дорогое» в церковь. Поэтому именно сюда направлена Евагелизационная программа Библейской Лиги. Метод, который используется в программе Избери Жизнь называется Личная Евангелизация (благовестие). Возможно, этот метод не выглядит столь масштабно, как проповедь на телевидении или стадионе. Но, статистика показывает, что большинство сегодняшних членов церквей (до 80%) пришли не через массовые мероприятия разного рода, но через Личную Евангелизацию. И именно на такую евангелизацию направлены усилия программы Библейской Лиги Избери Жизнь.
Esteroides anabolizantes; Andrógenos sintéticos; Hipogonadismo hipogonadotrópico; Azoospermia; Disfunción eréctil; Ginecomastia
Anabolic steroids; Synthetic androgens; Hypogonadotropic hypogonadism; Azoospermia; Erectile dysfunction; Gynecomastia, comprar esteroides.
Los esteroides androgénicos anabolizantes (comprar esteroides) son andrógenos sintéticos derivados de la testosterona, denominados así por ejercer acciones androgénicas y anabolizantes imposibles de disociar, probablemente debido a la existencia de un único receptor de andrógenos. Inicialmente, el interés por los EAA se debió exclusivamente a su presumible uso terapéutico; sin embargo, la mayoría de los sintetizados en los últimos 50 años carecen de una aplicación clínica real. En la última década, varios estudios han evaluado la prevalencia del abuso de EAA con fines no terapéuticos por deportistas, especialmente culturistas y atletas de alta competición, para mejorar su rendimiento atlético, usuarios de gimnasios y jóvenes que simplemente persiguen mejorar su aspecto físico. Según un estudio realizado en la Unión Europea (UE) en 2002, el 5,7% de los usuarios de gimnasio consumía habitualmente EAA, el equivalente a 1 millón de usuarios en la UE y unos 20.000 en España, aunque en nuestro país no hay cifras oficiales. Alrededor de la venta de estas sustancias hay un auténtico mercado esteroides y anabolizantes negro, las cuales se pueden obtener fácilmente a través de internet, en los gimnasios o mediante otras fuentes, como drogas de uso veterinario, por lo que se han convertido en un problema de salud pública en muchos países. La administración de dosis muy superiores a comprar esteroides las fisiológicas induce a la aparición de efectos secundarios. Destacan las alteraciones en la función sexual y reproductiva, objeto de esta revisión, así como alteraciones hepáticas, metabólicas, hematológicas, cardiocirculatorias, músculo-esqueléticas y psicológicas.
The anabolic-androgenic steroids (AAS) are synthetic androgens derived from testosterone, called in that way due to the appearance of anabolic and androgenic actions impossible to dissociate. Perhaps is due to the existence of a single androgen receptor (AR). At the beginning, the interest for the AAS was extremely exclusive for therapeutic use, however in the last fifty years, most of the synthesizers are lack of real clinical application. In the last decade, several studies evaluated the popularity abuse of AAS with non-medical use by athletes, especially bodybuilders and elite athletes to improve their athletic performance, gym users or just young people whom just want to improve and get better their physical appearance. In 2002, according to a study done in European Union (EU), 5.7% of the gym users were usually consuming AAS. Although there aren’t official esteroides y anabolizantes figures, the equivalent is to 1 million users in EU and 20.000 in Spain. There is a genuine black market surrounding the sale of these substances were can be easily obtained through internet, in the gyms or in other sources such as drugs of veterinary use, becoming a public health problem in many countries. The usage of doses more than the physiological ones, leads to side effects. Emphasizing the reproductive and comprar esteroides sexual function alterations, aim of this review, as well as the hepatic, metabolic, hematologic, cardio-circulatory, skeletal-muscle and psychological alterations.
Fisiofarmacología de los ándrógenos y esteroides androgénicos anabolizantes
Los andrógenos desempeñan un papel crucial en la virilización del tracto urogenital, y en consecuencia en el desarrollo del fenotipo masculino, que se inicia comprar esteroides entre las 7 y las 12 semanas de desarrollo embrionario. Por la expresión del factor determinante testicular o gen SRY (sex determining region Y), localizado en el brazo corto del cromosoma Y(Yp), las gónadas indiferenciadas evolucionan a testículos fetales, que producirán dos hormonas: a) la anti-Mülleriana (AMH), encargada de la regresión de los conductos de Müller, y b) la testosterona, necesaria para la formación, a partir de los conductos de Wolf, del epidídimo, vasos deferentes y vesículas seminales, así como para el desarrollo de la próstata, pene y escroto. Los andrógenos tienen efectos androgénicos, relacionados con el desarrollo de los órganos sexuales y de los caracteres sexuales esteroides y anabolizantes secundarios y anabólicos, en relación a los cambios que se producen en órganos y tejidos no reproductivos (tabla 1). En el varón adulto, la producción media de testosterona es de unos 7 mg/día13, el 95% se secreta en las células de Leydig del testículo, bajo el estímulo de la hormona luteinizante (LH) de la adenohipófisis, y el 5% en la corteza suprarrenal. Como el resto de esteroides, su estructura deriva de la molécula del ciclopentanoperhidrofenantreno, hidrocarburo policíclico de 17 átomos de carbono, constituido por cuatro anillos: un ciclopentano y tres anillos resultado de la saturación del fenantreno. De esta estructura se deriva la molécula de colesterol, que es captado por las células de Leydig a través de receptores de lipoproteínas de baja densidad o lipoproteínas de alta densidad, o generado ex novo mediante vías de síntesis o a partir de ésteres de colesterol. En el retículo endoplásmico liso, el colesterol es transformado sucesivamente por enzimas mitocondriales en pregnenolona, 17-hidroxi-pregnenolona, dihidroepiandrosterona, androstenodiol y androstenodiona, y finalmente en testosterona, cuya molécula está formada por 19 átomos de carbono, con una doble ligadura entre C4 y C5, un átomo de oxígeno en C3 y un radical hidroxilo (OH) en C17 (fig. 1). Sólo el 2-3% de la testosterona se encuentra disuelta en la sangre de forma libre (TL). En el plasma, la testosterona circula fundamentalmente unida a dos proteínas: la globulina ligadora de hormonas sexuales (SHBG, del inglés sex hormone binding globulin) y la albúmina. Entre el 35 y el 60% de la testosterona total (TT) se fija a la SHBG, glucoproteína hepática expresada también en otros tejidos diana de los andrógenos y los estrógenos, como los epitelios prostático y mamario14, y en los espermatozoides, en los que se concentra en el acrosoma15. La SHBG es similar a la ABP (androgen binding protein), producida en la célula de Sertoli y que esteroides y anabolizantes fija la testosterona comprar esteroides intratubular, diferenciándose tan solo en el número de oligosacáridos que contienen16. Ambas están codificadas por el mismo gen, localizado en el brazo corto del cromosoma 17 (p12-p13)17.
I preceded Mr. Omer, in compliance with his request; and after showing me a roll of cloth which he said was extra super, and too good mourning for anything short of parents, he took my various dimensions, and put them down in a book. While he was recording them he called my attention to his stock in trade, and to certain fashions which he said had ‘just come up’, and to certain other fashions which he said had ‘just gone out’.
‘And by that sort of thing we very often lose a little mint of money,’ said Mr. Omer. ‘But fashions are like human beings. They come in, nobody knows when, why, or how; and they go out, nobody knows when, why, or how. Everything is like life, in my opinion, if you look at it in that point of view.’
He then called down a little break-neck range of steps behind a door: ‘Bring up that tea and bread-and-butter!’ which, after some time, during which I sat looking about me and thinking, and listening to the stitching in the room and the tune that was being hammered across the yard, appeared on a tray, and turned out to be for me.
It was no other than Tommy Traddles who gave me this piece of intelligence. He was the first boy who returned. He introduced himself by informing me that I should find his name on the right- hand corner of the gate, over the top-bolt; upon that I said, ‘Traddles?’ to which he replied, ‘The same,’ and then he asked me for a full account of myself and family.
It was a happy circumstance for me that Traddles came back first. He enjoyed my placard so much, that he saved me from the embarrassment of either disclosure or concealment, by presenting me to every other boy who came back, great or small, immediately on his arrival, in this form of introduction, ‘Look here! Here’s a game!’ Happily, too, the greater part of the boys came back low-spirited, and were not so boisterous at my expense as I had expected. Some of them certainly did dance about me like wild Indians, and the greater part could not resist the temptation of pretending that I was a dog, and patting and soothing me, lest I should bite, and saying, ‘Lie down, sir!’ and calling generic levitra me Towzer. This was naturally confusing, among so many strangers, and cost me some tears, but on the whole it was much better than I had anticipated.
I felt it rather hard, I must own, to be made, without deserving it, the subject of jokes between the coachman and guard as to the coach drawing heavy behind, on account of my sitting there, and as to the greater expediency of my travelling by waggon. The story of my supposed appetite getting wind among the outside passengers, they were merry upon it likewise; and asked me whether I was going to be paid for, at school, as two brothers or three, and whether I was contracted for, or went upon the regular terms; with other pleasant questions. But the worst of it was, that I knew I should be ashamed to eat anything, when an opportunity offered, and that, after a rather light dinner, I should remain hungry all night – for I had left my cakes behind, at the hotel, in my hurry. My apprehensions were realized. When we stopped for supper I couldn’t muster courage to take any, though I should have liked it very much, but sat by the fire and said I didn’t want anything. This did not save me from more jokes, either; for a husky-voiced gentleman with a rough face, who had been eating out of a sandwich-box nearly all the way, except when he had been drinking out of a bottle, said I was like a boa-constrictor who took enough at one meal to last him a long time; after which, he actually brought a rash out upon himself with boiled beef.
We might have gone about half a mile, and my pocket-handkerchief was quite wet through, when the carrier stopped short. Looking out to ascertain for what, I saw, to MY amazement, Peggotty burst from a hedge and climb into the cart. She took me in both her arms, and squeezed me to her stays until the pressure on my nose was extremely painful, though I never thought of that till afterwards when I found it very tender. Not a single word did Peggotty speak. Releasing one of her arms, she put it down in her pocket to the elbow, and brought out some paper bags of cakes which she crammed into my pockets, and a purse which she put into my hand, but not one word did she say. After another and a final squeeze with both arms, she got down from the cart and ran away; and, my belief is, and has always been, without a solitary button on her gown. I picked up one, of several that were rolling about, and treasured it as a keepsake for a long time.
Having by this time cried as much as I possibly could, I began to think it was of no use crying any more, especially as neither Roderick Random, nor that Captain in the Royal British Navy, had ever cried, that I could remember, in trying situations. The carrier, seeing me in this resolution, proposed that my pocket- handkerchief should be spread upon the horse’s back to dry. I thanked him, and assented; and particularly small it looked, under those circumstances.
I never shall forget the waking, next morning; the being cheerful and fresh for the first moment, and then the being weighed down by the stale and dismal oppression of remembrance. Miss Murdstone reappeared before I was out of bed; told me, in so many words, that I was free to walk in the garden for half an hour and no longer; and retired, leaving the door open, that I might avail myself of that permission.
I did so, and did so every morning of my imprisonment, which lasted five days. If I could have seen my mother alone, I should have gone down on my knees to her and besought her forgiveness; but I saw no one, Miss Murdstone excepted, during the whole time – except at evening prayers in the parlour; to which I was escorted by Miss Murdstone after everybody else was placed; where I was stationed, a young outlaw, all alone by myself near the door; and whence I was solemnly conducted by my jailer, before any one arose from the devotional posture. I only observed that my mother was as far off from me as she could be, and kept her face another way so that I never saw it; and that Mr. Murdstone’s hand was bound up in a large linen wrapper.
If it had been Aladdin’s palace, roc’s egg and all, I suppose I could not have been more charmed with the romantic idea of living in it. There was a delightful door cut in the side, and it was roofed in, and there were little windows in it; but the wonderful charm of it was, that it was a real boat which had no doubt been upon the water hundreds of times, and which had never been intended to be lived in, on dry land. That was the captivation of it to me. If it had ever been meant to be lived in, I might have thought it small, or inconvenient, or lonely; but never having been designed for any such use, it became a perfect abode.
It was beautifully clean inside, and as tidy as possible. There was a table, and a levitra plus Dutch clock, and a chest of drawers, and on the chest of drawers there was a tea-tray with a painting on it of a lady with a parasol, taking a walk with a military-looking child who was trundling a hoop. The tray was kept from tumbling down, by a bible; and the tray, if it had tumbled down, would have smashed a quantity of cups and saucers and a teapot that were grouped around the book. On the walls there were some common coloured pictures, framed and glazed, of scripture subjects; such as I have never seen since in the hands of pedlars, without seeing the whole interior of Peggotty’s brother’s house again, at one view. Abraham in red going to sacrifice Isaac in blue, and Daniel in yellow cast into a den of green lions, were the most prominent of these. Over the little mantelshelf, was a picture of the ‘Sarah Jane’ lugger, built at Sunderland, with a real little wooden stern stuck on to it; a work of art, combining composition with carpentry, which I considered to be one of the most enviable possessions that the world could afford. There were some hooks in the beams of the ceiling, the use of which I did not divine then; and some lockers and boxes and conveniences of that sort, which served for seats and eked out the chairs.
I was born with a caul, which was advertised for sale, in the newspapers, at the low price of fifteen guineas. Whether sea-going people were short of money about that time, or were short of faith and preferred cork jackets, I don’t know; all I know is, that there was but one solitary bidding, and that was from an attorney connected with the bill-broking business, who offered two pounds in cash, and the balance in sherry, but declined to be guaranteed from drowning on any higher bargain. Consequently the advertisement was withdrawn at a dead loss – for as to sherry, my poor dear mother’s own sherry was in the market then – and ten years afterwards, the caul was put up in a raffle down in our part of the country, to fifty members at half-a-crown a head, the winner to spend five shillings. I was present myself, and I remember to have felt quite uncomfortable and confused, at a part of myself being disposed of in that way. The caul was won, I recollect, by an old lady with a hand-basket, who, very reluctantly, produced from it the stipulated five shillings, all in halfpence, and twopence halfpenny short – as it took an immense time and a great waste of arithmetic, to endeavour without any effect to prove to her. It is a fact which will be long remembered as remarkable down there, that she was never drowned, but died triumphantly in bed, at ninety-two. I have understood that it was, to the last, her proudest boast, that she never had been on the water in her life, except upon a bridge; and that over her tea (to which she was extremely partial) she, to the last, expressed her indignation at the impiety of mariners and others, who had the presumption to go ‘meandering’ about the lulast world. It was in vain to represent to her that some conveniences, tea perhaps included, resulted from this objectionable practice. She sildenafil 100mg always returned, with greater emphasis and with an instinctive knowledge of the strength of her objection, ‘Let us have no meandering.’
All day Buck brooded by the pool or roamed restlessly about the camp. Death, as a cessation of movement, as a passing out and away from the lives of the living, he knew, and he knew John Thornton was dead. It left a great void in him, somewhat akin to hunger, but a void which ached and ached, and which food could not fill, At times, when he paused to contemplate the carcasses of the Yeehats, he forgot the pain of it; and at such times he was aware of a great pride in himself,–a pride greater than any he had yet experienced. He had killed man, the noblest game of all, and he had killed in the face of the law of club and fang. He sniffed the bodies curiously. They had died so easily. It was harder to kill a husky dog than them. They were no match at all, were it not for their arrows and spears and clubs. Thenceforward he would be unafraid of them except when they bore in their hands their arrows, spears, and clubs.